Naked Foal Syndrome (NFS)
Gene or Region: ST14
Reference Variant: G
Mutant Variant: T
Affected Breeds: Akhal Teke
Research Confidence: Moderate confidence, strong correlation in larger studies
Explanation of Results: nfs/nfs = homozygous for Naked Foal Syndrome, trait likely expressed/likely lethal nfs/n = heterozygous for Naked Foal Syndrome, carrier n/n = no variant detected
General Description
Naked Foal Syndrome (NFS) is a recessive genetic disorder resulting in the birth of foals with little to no hair and a general weakness with death occurring early in life (weeks to months).
References
Bauer, A., Hiemesch, T., Jagannathan, V., Neuditschko, M., Bachmann, I., Rieder, S., Mikko, S., Penedo, M. C., Tarasova, N., Vitková, M., Sirtori, N., Roccabianca, P., Leeb, T., & Welle, M. M. (2017). A Nonsense Variant in the ST14 Gene in Akhal-Teke Horses with Naked Foal Syndrome. G3 (Bethesda), 7(4), 1315-1321. doi: 10.1534/g3.117.039511
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